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Highs and lows. Genetic susceptibility to daily events Sicorello, Maurizio; Dieckmann, Linda; Moser, Dirk; Lux, Vanessa; Luhmann, Maike; […] Zeitschriftenbeitrag | In: PLoS ONE | 2020 40505 Endnote: Autor*innen: Sicorello, Maurizio; Dieckmann, Linda; Moser, Dirk; Lux, Vanessa; Luhmann, Maike; Neubauer, Andreas B.; Schlotz, Wolff; Kumsta, Robert
Titel: Highs and lows. Genetic susceptibility to daily events
In: PLoS ONE, (2020) 15, S. e0237001
DOI: 10.1371/journal.pone.0237001
URN: urn:nbn:de:0111-dipfdocs-232683
URL: https://nbn-resolving.org/urn:nbn:de:0111-dipfdocs-232683
Dokumenttyp: 3a. Beiträge in begutachteten Zeitschriften; Aufsatz (keine besondere Kategorie)
Sprache: Englisch
Schlagwörter: Person; Gen; Serotonin; Einflussfaktor; Umgebung; Ereignis; Emotionaler Zustand; Belastung; Verhaltensgenetik; Smartphone; Online; Befragung; Bochum; Deutschland
Abstract (english): Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17-36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a within-person level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system's general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.
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