-
-
Author(s): Kühn, Simone; Schmiedek, Florian; Noack, Hannes; Wenger, Elisabeth; Bodammer, Nils C.; Lindenberger, Ulman; Lövden, Martin
Title: The dynamics of change in striatal activity following updating training
In: Human Brain Mapping, 34 (2013) 7, S. 1530-1541
DOI: 10.1002/hbm.22007
Publication Type: 3a. Beiträge in begutachteten Zeitschriften; Aufsatz (keine besondere Kategorie)
Language: Englisch
Keywords: Aktivität; Arbeitsgedächtnis; Gehirn; Messung; Neurophysiologie; Training
Abstract: Increases in striatal activity have been suggested to mediate training-related improvements
in working-memory ability. We investigated the temporal dynamics of changes in task-related brain
activity following training of working memory. Participants in an experimental group and an active
control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental
group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental
group an initial increase of working-memory related activity in the functionally defined
right striatum and anatomically defined right and left putamen was followed by decreases, resulting in
an inverted u-shape function that relates activity to training over time. Activity increases in the striatum
developed slower in the active control group, observed at the second posttest after more than 50
days of training. In the functionally defined left striatum, initial activity increases were maintained after
more extensive training and the pattern was similar for the two groups. These results shed new
light on the relation between activity in the striatum (especially the putamen) and the effects of working
memory training, and illustrate the importance of multiple measurements for interpreting effects
of training on regional brain activity.
DIPF-Departments: Bildung und Entwicklung