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Author
Sicorello, Maurizio; Dieckmann, Linda; Moser, Dirk; Lux, Vanessa; Luhmann, Maike; Neubauer, Andreas B.; Schlotz, Wolff; Kumsta, Robert:

Title:
Highs and lows
Genetic susceptibility to daily events

Source:
In: PLoS ONE, (2020) 15 , e0237001

URL of full text:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237001

Language:
Englisch

Document type
3a. Beiträge in begutachteten Zeitschriften; Aufsatz (keine besondere Kategorie)

Schlagwörter:
Person, Gen, Serotonin, Einflussfaktor, Umgebung, Ereignis, Emotionaler Zustand, Belastung, Verhaltensgenetik, Smartphone, Online, Befragung, Bochum, Deutschland


Abstract(englisch):
Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17-36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a within-person level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system's general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.


DIPF-Departments:
Education and Human Development

Notes: